CKDu Sri Lanka - හේතුවක් නැති මාරාන්තික රෝගය

CKDu Sri Lanka kedney disease chronic kidney disease kidney disease

BY DR NISHANTHA KUMARASINGHE Sri Lanka has a population of approximately 20 million and agriculture is a major component of the economy.Chronic kidney disease (CKD) is a major burden on the healthcare system of Sri Lanka. Diabetes, hypertension, and the various forms of glomerulonephritis are well-recognized etiologies.With increasing prevalence of non-communicable diseases, in particular diabetes and hypertension, the burden of CKD is expected to rise. Since the 1990s, a new CKD, where no obvious cause is identifiable, has been described in Sri Lanka. This new condition has resulted in a rise in the incidence of CKD in rural Sri Lanka, and has been aptly named chronic kidney disease of unknown etiology (CKDu).Alternate suggested names for this condition include chronic agricultural nephropathy (CAN) and CKD of multifactorial origin (CKD-mfo).Similar entities with unknown cause for CKD exist in other parts of the world. Environmental agents and conditions, such as heavy metals and industrial chemicals, have been linked to the development of CKDu in other parts of the world. In this systematic review, we seek to synthesize research on the cause(s) and treatment modalities of CKDu in Sri Lanka. kiWe describe the epidemiology, clinical features, and diagnosis of this new entity in Sri Lanka, and explore the implicated etiologies.chronic kidney disease (disease or medical condition)